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KMID : 0387420100210020103
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Korean Society of Oriental Neuropsychiatry
2010 Volume.21 No. 2 p.103 ~ p.123
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Effects of Tianwangbuxin-dan, Wendan-tang, Guipi-tang on the expression of and melatonin receptors in C6 glial cells
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Cho Yun-Song
Kim Bo-Kyung
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Abstract
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Objectives : This study was to investigate the effect of several herbal prescriptions such as Tianwangbuxindan qu zhusha, Tianwangbuxindan, Wendantang, Guipitang on the level of and melatonin receptors in C6 glial cells.
Methods : For this study, we exposed of C6 cells to several herbal prescriptions resulted in non-cytotoxic in various dose as measured by MTT assay, trypan blue count, morphology change and DAPI stain.
Results : Tianwangbuxindan qu zhush and Tianwangbuxindan induced the levels of melatonin receptor expression in a dose-dependent manner without altering the level of melatonin receptor expression. However, the treatment with Wendantang, Guipitang don’t effect of and melatonin receptor expression.
Conclusions : This results suggest that Tianwangbuxindan can be a promising the regulation of melatonin receptor synthesis, and further studies will be needed to clarify the mechanism.
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KEYWORD
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Tianwangbuxin-dan qu zhusha, Tianwangbuxin-dan, Wendan-tang, Guipi-tang, and melatonin receptors
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